** In the time it took me to type this, IlyaV also responded with a similar post - but, here's my take **
One thing that I notice is that in the picture with the color buttons, the unit not only seems to have the newer volume / page up - down button changes but also a design change to the center 4 way navigation button. I wasn't at CES - so all of my analysis is based on pics - but it appears to me that in the CES pics and in Mike's earlier picture that the 4 way nav and "ok" button is 1 large multi-functional button while the BestBuyPlasma image seems to have a separate "ok" center button in the color shot. I think I like this better for backlight and tactile purposes as well as addressing concerns from people who have had problems with those sort of single button designs in the past. I could go either way with the color buttons in general - but have to wonder how the color would affect the backlighting (I am assuming that it will have the same blue backlighting) - and thus, the black text might not be as readable with color buttons.
While I was originally really turned off by the design of this remote when comparing it to the 659, the more I think about how I use my equipment, the more I realize that Harmony has come up with close to the perfect layout. They have addressed the PVR issues and the slippery plastic coating on the 659 key issues - and given me every key that I need on a regular basis as a PVR user (both Replay and Motorola 6208). However, as many others both here and at Remote Central have mentioned, I actually (after much thought) decided that Harmony was on to something with their original design and now would have preferred the page up / page down in their original locations. For me, this has to do with the use of the Motorola DCT Series Digital Cable boxes that are used (at least in some cities) by most of the major providers (Comcast, Cox, RCN, etc.) These boxes use the Page Up / Down button in the guide - and do not allow for the use of the channel up / down button as an alternative.
Oh well - either way, I am ordering and looking forward to this remote being the best design from Harmony Yet! Now if they just let power users pay more for the XML abilities and/or have the ability to create activities within activities (such as Watch TV - then Watch HD, Watch SD, etc.) - we have a perfect fit for my needs!