Lens shift question?

I have a quick question. Do those of you who use use vertical and/or horizontal lens shift see ANY degradation in the quality or clarity of the image? I am considering putting a Z5 or AX100 in a setup that currently has no offset so if I put this projector in the same place I will have to use the vertical lens shift at about 50% of the image height. Basically do you think this level of lens shift will affect the image? Any help would be appreciated?