I'm with the Iceman on this one: tubes for the line level signal path and SS for the big power. Again, your call, but big "non-tube" sounding tube based amps are generally expensive, put out the heat, and are prone to fail every 3 to 5 years. (No hate mail please - I've owned and loved a couple of classic tube amps). My amp is a hybrid with small signal tubes in the line stage and SS transistors kicking out 600W RMS per channel into 4 ohm loads with 80 AMP peaks. Can you say bass control
Personally, I think the hybrid approach is the best compromise for taking the harshness out of digital sources w/o to much concern for tube failures. Pre-amp level tubes typically last 10, 20, or more years.
An issue with tube pre-amps, though, is that they are generally only available for stereo setups. So if you're looking for an HT setup, your choices are limited. In that case, you can look for a hybrid amp or tubes to power your CDP line stage. There are other options, but those are the two most common solutions.
Have fun and if you go for the big VTL power amp I'm sure it will sound incredible!