Cool, picked mine up today. I figured they'd show up at the BB stores before any websites, because I've run into that in the past with Logitech stuff, stuff showing up at the store before the BB website or Logitech itself shows it's for sale.
Anywho, so went to a store near work after I got off, they didn't have any. But the store near home did. I'm currently using a MX500, so that's going to be what I compare it to. It'll take some getting use to, not having a ton of hard buttons compared to the MX500.
Like someone else mentioned, I too got prompted to create a new ID after installing the software, I was pretty "pfft, bozos". I found hitting the "Previous" button took me back to a login/register screen, which I was never shown in the first place. Also found if you go to the Logi site, that it's offering the 7.3 software, but if I go to Apple's download page, it has a link for the 7.4 software, and from there you can choose your flavor.
I'm using Vista 64, so half the time I find devices not working, but didn't have any REAL issues, other than when I plugged in the One, Vista told me the device driver didn't install, but that didn't stop the Harmony software from talking to the remote.
I do like that the remote is lighter than the MX500, and haven't had any problems yet dealing with 6 soft buttons with my fat fingers, but I haven't used it too much yet. At this point, I've just done the initial setup and I'm letting it charge up now.