with full disclosure, i did not pay for either remote, but if i had the money i'd spring the extra $150 for a 1100. i have both the 1100 and the 1000 inhouse for testing and i wouldn't even give the 1000 away to anyone. it was a good concept, but poorly implemented and buggy. mine only froze once, but i've read of others' freezing often enough to instigate a return or exchange. the 1100 feels like the 1000 do-over. i have read of a 1000 fix via fw update, but i haven't kept up on that. you might research to see if it still has problems.
1. both operate primarly the same way as activity-based remotes; press 'watch tv' and the remotes run through and turn on all necessary equipment, switches inputs properly, etc. they also use the harmony 'smart state' technology .however, the 1100 runs a more stable and refined os than the 1000.
2. unfortunately that 1100 os does not support sequences (macros assigned to a command button from within an activity). the 1000 does.
3. the 1100 allows the user to assign different logitech-supplied icons to many of the command buttons within activities (ie. graphic button icons for red, green, blue, yellow; tivo thumbs up/down; xbox; ps3; and many others.). the 1000 does not allow that flexibility.
4. both allow the addition of rf modules (for extra $$) for components not within line-of-sight.
5. the 1100 has a matte black finish, the 1000 is silver. and the 1100 has hard embossed "bumps" in the front bezel around the touch screen which helps a little with mapping your fingers to the touch screen's buttons (see next note below).
with all that said, i still prefer the one-handed wand remotes like the harmony one or 900. with the tablet i have to constantly look down to see what button i'm pushing on the touchscreen, holding the remote with one hand and operating with the other. with the one and 900, the fingers of one hand mapped themselves to the hard buttons over time. and if you need rf, the 900 comes with the rf modules in the kit for one price. but now i'm off the subject...