Sure, but watch out for the transcoding from FLAC to WMA or WAV, just make sure you have a processor sufficient to handle the load.
As to what formats the AV8003 handles, follow the bouncing assumptions...
Assume the TVIX software/card as posted earlier was selected to integrate for the media player by Marantz.
Marantz stated the media player is not supporting FLAC - that rules out the HD media players as the integration base since they all support FLAC.
This leaves the M-3100U, and C-2000U, both 1st gen non-HD players. Formats supported are up to 1080i using component, but not clearly spelled out:
Video:AVI(3.x, 4.x, 5.x, Xvid), MPG, DAT, VOB, .IFO, ISO
Music:MP3, Ogg Vorbis, WMA, Multi channel digital audio
Notice that the formats are all lossy on the audio side (depending on what multi-channel audio means - on the 2000 it says DTS passthrough so I suspect that is it).
I tried to check the manual for video format resolutions, but their ftp server is too slow.
Compare this codec list to the TVIX HD media players which all support FLAC and lossless audio and MPEG 4 AVC/H2.64 and VC1 video with HDMI output.
If this is correct, and you want lossless audio, I would expect to connect an SB3 to it via S/PDIF.
Also if correct, it does not support the latest HD video codecs, which is unfortunate as there is considerable advantage in using H.264 when building an HD DVR. So if you want HD DVR playback, this would not really do the job. It is of course fine for ripped SD DVD playback.
From my perspective, again if the assumptions are correct, I would likely continue to use a separate audio and video player to get lossless audio and HD video codecs.
An SD video player & lossly audio player would not be a great feature match to an HD HBR SSP, but is probably a better fit to their price point.
All of this, of course, may be incorrect, so we will just have to await Marantz formal announcement of specs to know for sure.