Well, after getting pretty loopy in the garage last night while working on my wife's car from the fuel and cleaners, I took a little bit of time to prime the box. I couldn't cut the 2 remaining panels for the sides (second baffle layer) because of the dust and my wife's car being under the knife opened up so that is still left to do.
I had some Killz'It sealer/primer from some time ago when I did my cabinets so I figured I would use that for the base sealant/primer. I also bought some Glidden grey primer/sealer yesterday that is made for use under dark coats. I cleaned the MDF of dust and taped off the OSB where the sub sits.
I mixed the Killz'It and poured some out. I started in the corners with a small brush and everything was fine or so I thought. Then I pulled out the small foam roller to hit the rest. I started rolling it out and noticed "chunks" in the paint. It seems that the latex congealed in the paint :grrrr

.
Maybe it was the lighting or maybe because I was pretty high

from the car stuff and now paint as well, but I didn't notice the chunks when I poured the paint. I thought they were air bubbles from shaking. I can actually pick the chunks out and they feel like soft gummy rubber between my fingers.
At this point in the night I said screw it and continued to roll out the primer for a few quick coats. I will sand it pretty good before I lay the Glidden primer on top to ensure an even surface. After the MDF is sealed and primed pretty good I will do some serious sanding before the black coats are applied.
Anyone see any issues with the primer I applies that can bite me in the ass later? Pics to follow shortly.