It can be done, but it isn't going to work like you want without a MiniDSP, Umik-1, and REW.
Auddysey has fantastical claims of what it "can do" with multiple subs. I've yet to see said claims stand up to reality when measured with REW and a Umik-1.
REW, Umik-1, and MiniDSP 2x4HD will get them playing nicely together. But not without some effort on your part.
MiniDSP 2x4HD, UMIK-1, REW... The holy trinity for running multiple subs.
Espon 5050UB, 120" screen, AppleTV4k, Harmony Elite, Sony UBP-X700, Pioneer Elite VSX-LX504, Outlaw 7000x, MiniDSP 2x4HD, 2x HSU TN1220HO subs, 2x HSU VTF-15H Mk2 subs, Defintive Technology speakers: CLR2002 x3 for FR, C, FL; BP2x SR & SL; BP1.2x SBL & SBR; ProMonitor 800 x4 height speakers.