You could design this space from the seating. Plant the seating row at 2/3rds room depth for smooth audio response, and carve off the front depth by employing an acoustically transparent
screen and screen wall. And with an acoustically transparent screen, you can raise the center channel or potentially use three identical speakers up front.
There is little benefit from sitting 16' from a screen. You give up brightness, with a screen size that is overly big, and you sit too far for your eyes to resolve 4K. Your speaker selection also needs to
be carefully considered as things like dome speakers are unlikely to be up to the task of playing reference levels at the seats.
The AT screen also allows you to easily acoustically treat the front wall and even host bass traps up front. And speaker finishes can be outright flat lack boring and rather cheap when it comes to some
subwoofer flat packs.
A counter as to for scope being smaller: I disabled the lower masking panel and rather preferred it, with a single row. Plans for the next room is hdtv shows, concerts and sports will have the larger 16x9 and scope will
be looked at as more intimate. I sure didn't know this would turn out that I rather prefer a single upper mask and all formats tied to the bottom of the screen, which is 16" off the floor. It'll also be pretty
simplistic to rebuild my masking system for an larger screen, using what I already own. Hdtv shows are important viewing for myself, and I got as far as buying an anamorphic lens and curved scope screen, which
will be flipped back into cash.
You don't need to raise your subs, and ideally you don't have them blowing on an acoustically transparent screen.