I finally got around to trying The Persistence, and I've concluded it's not for me. I don't think the game is bad, but it's very much a rogue-like game, which is a genre I don't play. (I've only tried one other rogue-like, the Mooncrash DLC for Prey, and didn't enjoy that either.)
The issue I have with rogue-likes isn't that the level maps are randomly generated each time. (In The Persistence, this isn't really a problem anyway, because you'll probably be playing slowly, and you're always able to view a complete map of the level by hitting the touchpad.) It's that dying costs so much that I don't feel like I can practice my skills. For example, you have to purchase your weapons, paying with carefully scrounged resources. If you die because you couldn't figure out how to use a weapon properly, you've lost every weapon you were carrying. You'll have to start over from the beginning and scrounge up more resources to buy them again. Some progress is maintained; if you've increased your maximum health, that carries over, but even with 200% health, I was dying after two hits from certain enemies.
The Persistence's main story campaign involves completing four objectives, and I notice that only 28.1% of players have been awarded the trophy for completing the first objective. That means less than a third of people who've played have finished the first quarter of the game, which is apparently the easiest part. I managed to get that far, but the completion rate for the second objective drops to 12.4%, and I can see why; I'm giving up. Maybe this is typical for rogue-like games, but it makes me wonder: are developers actually happy when most of their customers never experience the vast majority of the game?
Anyway, if you're a fan of rogue-likes and want to try one in VR, you'll probably like this game.