"Speaker Wire Make a Difference?"
Yes, most definitely, in the case of many of the most expensive and exotic cable designs. Why? Because these are designed, engineered, and manufactured specifically to produce a certain "house sound", by incorporating various gizmos and devices into the cables. They are essentially being used as tone controls, so that users can fine tune their systems. Some even are made with materials such as graphene and some employ magnets along the cables. I actually don't see how they could possibly sound the same at all, given the alterations and disparate designs employed in them. Now, as to more conventional copper cables, it's probably unlikely to hear much difference from them.
FAMILY ROOM--Legacy Signature II towers(Front L/R), PSB Image 5T towers(Surrounds), Polk LSiM706 center, Denon AVR-X5200W, Krell FPB 400cx, AR ES-1 turntable w/ Audioquest 404-B cartridge, Oppo UDP-203 UHD Blu-ray Player, RCA HD-DVD player, Sony 75" 900E.
MASTER BEDROOM--Dynaudio Audience 82 tower speakers, Outlaw LFM-1 sub, Onkyo TX-NR809, Oppo BDP-83 Universal Disc Player, Panasonic 60-ST60 plasma TV.