Will try to answer your question
Having a sub down firing or front firing does not matter.
What is not recommended, is mixing a port sub with a seal one due to phase shift. Making them very difficult to intergrade together.
But both of your subs are port. At this point, the biggest downside. If you use an automatic calibration system, and if it is a true dual sub AVR.
The stronger one will be adjusted to the weaker one. But in most AVR, only use an internal Y-splitter. The same has having only one sub output on the AVR, and using a Y-splitter.
I would say, yes. You can use both subs in your case. Just be aware if one go a little deeper than the other, your lowest response may suffer a little.
Only trying them together will tell, and even then. At that point, you only have to worry about matching their volume level and phase for there distance to each other.
Darth