You need to make sure of the location that you cut the hole in especially on engineered floor joist. Make sure to check the allowed locations from your floor truss manufacturer or consult the Uniform Building Code for solid wood joist. Off the top of my head I believe that most Engineered Joists generally require a 2" hole to be in the first 1/3 of the overall span but that may depend on the size of the joist. Although I own a development, company its been several years since I have had a reason to worry about this issue but I am sure for a 2+" hole you will want to check it out before you drill.
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