Try changing the 0 to a 1 under deffered overlay in the aspect section of the ini file. This fixed it for me. Same scenario, Radeon latest drivers etc.
Hope this helps, Andrew.
PS. To the guys responsible for Dscaler. Thanks for a truely excellent piece of software. Very, very stable for me, with seemingly improved picture quality in latest version. What a shame software you pay money for can't be as good.
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