I had the original Take 5 in my bedroom and thought they sounded good until I bought some bookshelf speakers. You're definitley making a compromise with satellites.
The Takes are definitely one of the better satellite systems if you have to go that route.
I've got a buddy with Take 5.2 setup in a large room. They just can't fill up all that space. If you're comparing it to just using the TV speakers, they yes its great but once you get some bookshelf speakers with a 5.25" driver or larger, you immediately notice how much better bookshelf speakers fill a large room.