Depends...my experience is that post-processing blurs the image too much to be of much use. Although I've heard good things about the newest awarpsharp (which tends to reduce artifacts simutanious with sharpening).
You can try introducing some light noise into the picture to cover up artifacts......which can also actually improve the image by restoring a film quality. Additionally, i find that the resize sharpening trick works really well for any source.
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