Don't forget 4AM Media Console. It seems to have the right balance of features and simplicity.
(Just my opinion here) I think of Mainlobby as being more of a home automation front-end program. It can do a lot of very cool things, but 4AM was a lot easier to set up for me and met my needs as just the front-end for my HTPC programs. It's also cheaper.
You ought to try the demos of both and see what meets your needs the best.
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