What subs are you looking at? The reason I ask is this: The Dayton 12" subwoofer can be had for around $150. The SVS PB-10 can be had for around $450 (x2 = $900). In this case, it's pretty obvious that the two 10" subs would be better.
If you assume that the 2 10's will cost the same as the one 12" then you'll probably have lower quality subs, but the advantage will be that you may be able to smooth your frequency response a little by having the two subs in different locations.
If you assume that the 2 10's will cost the same as the one 12" then you'll probably have lower quality subs, but the advantage will be that you may be able to smooth your frequency response a little by having the two subs in different locations.