First thing you need to do is determine if it is a dust blob. By using the focus, a dust blob should be able to be brought into some detail. Assuming it is, you then have to go through the cleaning procedure:
First, thoroughly clean the filter and the housing underneath it. Then, remove the top and turn the projector on its side. Using a can of "canned air" that has been blown down about a third (to prevent any liquid from coming out), blow around the entire interior of the projector to remove dust. Then, blow all around the the three panel assembly which you will see clearly with the top off. BE VERY CAREFUL TO KEEP THE CAN LEVEL AND DON'T AGITATE IT TOO MUCH AS YOU MOVE IT AROUND. You don't want any liquid to come out!
Make sure the inside of the top is clean as well, reassemble and check your work.
Hope this helps.
Dan