If your MLP and sub are at least at the 2/3 of the long wall and there are a few placement options to move your sub around to try and find the best location to give the best frequency coverage at you MLP then it should work pretty well. One factor that can come into play is localisation if you set your mains X-overs to high and i'm guessing it will be a bit more challenging blending the bass in with the front sound stage, but thats "guessing" as i havent set up any of my systems that way.
I've read many posts of enthusiasts that have been quite happy with this set up however many of them are more experienced than myself in fine tuning.