Here are some suggestion that I have read:
1) Build 90 degree angles into the duct. Typically with duct board. These angles will decrease noise moving through the ducts, but also increase the resistance for airflow. Thus possibly making your system have to work a little harder and increasing your bill a little. Both are probably negligable with only a turn or two.
2) Insulate existing ducts and plenums
3) Use an over sized grill for vents/returns to decrease air velocity and therfore airflow noise through the grill.
1) Build 90 degree angles into the duct. Typically with duct board. These angles will decrease noise moving through the ducts, but also increase the resistance for airflow. Thus possibly making your system have to work a little harder and increasing your bill a little. Both are probably negligable with only a turn or two.
2) Insulate existing ducts and plenums
3) Use an over sized grill for vents/returns to decrease air velocity and therfore airflow noise through the grill.