First I'd crack open that harmony and clean the button contacts. That'll work for all but the clicky keys. If it's hopeless, take a look at your other remotes. If there's a 6-pin connector under the battery door, you can program them from your PC similar to harmony, with the right cable. Check out the links in my sig. If you're short on cash, check out the refurb harmony deals on amazon. If you're not interested in programming the comcast or vizio from your PC, post the model numbers of the devices you want to control and we may be able to find codes. If you have partially working codes, tell us those too.