Acoustics, and the speaker room interface is the single most important aspect that matters the most, and one has some measure of impact upon. Bi-lateral symmetry is a plus wrt imaging and optimizing acoustics. So, the two obvious options that serve you well in this regard, are the top right shoe-box type rectangle, which is a secondary option. However the preferred option for me, even with the support column, is the lower right of the diagram.
I'd place the display in the lower right corner, and the entire HT at a diagonal direction. This offers many things, however foremost is the re-direction (an often applied tool in studios) of the lateral energy from the mains. Secondly, it offers a diffuse, infinitely complex rear wall characteristic. Yes, the support beam is somewhere adjacent to the LP, but it's a small, one or two person LP so after treating the column, it's rendered benign.
After addressing some acoustic issues with moderate diffusion and absorption, and generous bass trapping, the ITU 5.1 arrayed Genelec mains/surrounds would cover the top, and a complement of Lab Gruppen powered Funky Wave LMS5400 18's would have the LF supported. Several dedicated, isolated 20 amp/120 volt circuits would power the speakers and front end electronics, and 2 20 amp 240 volt circuits would supply power for the subwoofer amplifiers.
Set up REW, or OmniMic, and find and address any aberrant behavior in the time, and frequency domains. Put in your favorite source material, sit back and enjoy.
It's all very simple.
