Not really, unless you drive like crazy and hit it very hard against the pickup truck bed walls. They come packed so they can absorb/resist certain rough handling. Just secure it really good with a nice foam or sheets so it does not move while you drive.
Larger LCD's have tip meters or shock meters on the box base and some are strapped to pallets keep it on the pallet if you can since transport would be more stable as that is how the freight carriers deliver the larger ones - make sure you keep it vertical as all glass is transported vertical since stress points could break laying flat - gravity wins with heavy glass laying flat and no insurance it you lose and hit a bad bump, pothole or sudden stops.
They are well protected but not intended to be moved horizontally.
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