That all depends on whether the USB port is for input (most likely) or output? It will depend on what settings the blu-ray player has for outputting (if at all) audio via the USB port? You will need to go into either the manual or the A/V settings on your blu-ray player to see if this is possible. As you don't mention your blu-ray player brand or model number, I cannot advise you any further. I'm sure others will be able to give you some advice as well. Good luck.