Presumably you would need multiple physical sound cards, with one tied to each virtual machine. Then you would install speakers in each room with speaker wire running from the speaker back to the PC location. Install a multi-channel amplifier at the PC location, connected to the outputs from your soundcards and the speakers for the respective rooms. Monoprice has USB over cat5 extenders (not USB 2 compatible).
Presumably you would need multiple physical sound cards, with one tied to each virtual machine. Then you would install speakers in each room with speaker wire running from the speaker back to the PC location. Install a multi-channel amplifier at the PC location, connected to the outputs from your soundcards and the speakers for the respective rooms. Monoprice has USB over cat5 extenders (not USB 2 compatible).