I am facing the same situation. New gear. Total Newbie. Denon AVS 750, 5.1 speaker set up, Samsung Frame 75", planning on using YouTube TV and Music, Netflix, not much else. Haven't crossed the threshold to gaming, Alexa/Assistant, etc. Open to thoughts on favorite devices/inputs.
I will put the 1-box in the wall behind the TV, so it would be easiest to only run 1 HDMI to the receiver (down the wall, under the floor, across the room in my case) and not have to get back there again. I am wondering if it makes sense to make any other connections up front, and if it ever makes sense or is possible to switch back and forth between signal from the receiver and direct to tv.
Thanks in advance! Jeff